- Supports 3D scaffolds, promotes cell proliferation and migration.
- As a biocompatible, biodegradable carrier for targeted or sustained drug release.
- Used in hydrogel or film form for studying tissue regeneration.
- Interacts with cytokines, chemokines, and adhesion molecules.
- Used to study its role in oxidative stress and tumor progression.
Hyaluronic Acid Sodium Salt
| CAS No: | 9067-32-7 |
| EINECS No: | 232-678-0 |
| Synonyms: | hyaluronic acid, HA, hyaluronan, sodium hyaluronate |
Product Summary
Hyaluronic acid is a naturally occurring, high-molecular-weight glycosaminoglycan composed of repeating disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine. It plays a critical role in maintaining extracellular matrix integrity, hydration, and tissue repair. It can be hydrolyzed by hyaluronidase. Purified hyaluronic acid is neutralized with sodium hydroxide (NaOH) to form sodium hyaluronate.
Biochemical Function & Mechanism of Action
Hyaluronic acid is highly hydrophilic, capable of retaining up to 1000 times its weight in water, contributing to skin elasticity, joint lubrication, and wound healing. It interacts with cell surface receptors like CD44 and RHAMM, triggering anti-inflammatory, anti-apoptotic, and angiogenic cellular responses.
Applications in Scientific Research
Packaging & Storage
- White or almost white lyophilized powder
- Store at room temperature
References
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- Brown MB, Jones SA. 2005: Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin, J Eur Acad Dermatol Venereol. 19(3):308–18.
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- Matou-Nasri S, et al. 2009: Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 and RHAMM-mediated signalling pathways involving Cdc2 and gamma-adducin, Int J Oncol. 35(4):761–73.
- Rahim A, et al. 2024: Hyaluronic acid: comprehensive review of a multifunctional biopolymer, Future J Pharm Sci. 10(63).
- Zhou L, et al. 2021: Role of CD44 in increasing the potency of mesenchymal stem cell extracellular vesicles by hyaluronic acid in severe pneumonia, Stem Cell Res Ther. 12:293.
- Beldman TJ, et al. 2017: Hyaluronan nanoparticles selectively target plaque-associated macrophages and improve plaque stability in atherosclerosis, ACS Nano. 11(6):5785–99.
- Cirillo N. 2023: The hyaluronan/CD44 axis: A double-edged sword in cancer, Int J Mol Sci. 24(21):15812.
- Gao Z. 2019: A redox-responsive hyaluronic acid-based hydrogel for chronic wound management, J Mater Chem B. 7:7494–7501.