Bilirubin
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Beta Glucanase
Bromelain
Chymotrypsin
Kallikrein
Lysozyme
Pancreatin
Papain
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Coenzyme A
Coenzyme A Trilithium
Coenzyme Q10
Beta Glucans
Chitosan
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Dextran Sulfate Sodium
Glucosamine HCl
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Rosemary Extract
Sodium Cholate
Bilirubin
Cytochrome C
Gastric Mucin
HCG
FSH
UTI
PMSG
Aprotinin
Asparaginase
Beta Glucanase
Bromelain
Chymotrypsin
Kallikrein
Lysozyme
Pancreatin
Papain
Pepsin
Streptokinase
Trypsin
Urokinase
Coenzyme A
Coenzyme A Trilithium
Coenzyme Q10
Beta Glucans
Chitosan
Chondroitin Sulfate
Dextran
Dextran Sulfate Sodium
Glucosamine HCl
Heparin Sodium
Heparinoid
Hyaluronic Acid
Rosemary Extract
Sodium Cholate
Jiagen Biotechnologies
Coenzymes

Coenzyme Q10

CAS No:303-98-0
EINECS No:206-147-9
Synonyms:Ubiquinone-10, Ubiquinone-50, CoQ10, Ubidecarenone, Q10

Product Summary

Coenzyme Q10 is a fat-soluble, vitamin-like compound naturally present in the mitochondria of most eukaryotic cells. It plays a critical role in the production of ATP (adenosine triphosphate) via the electron transport chain, acting as an essential electron carrier in oxidative phosphorylation. Coenzyme Q10 also functions as a potent lipophilic antioxidant, protecting cellular membranes and lipoproteins from oxidative damage. CoQ10 is soluble in acetone, chloroform and ether, insoluble in water.

  • Formula: C59H90O4
  • Formula Molecular Weight: 863.34

Mechanism of Action

Coenzyme Q10 exists in both oxidized (ubiquinone) and reduced (ubiquinol) forms, allowing it to shuttle electrons between Complex I/II and Complex III in the mitochondrial inner membrane. Its redox cycling capability also enables it to neutralize reactive oxygen species (ROS) and regenerate other antioxidants, such as vitamin E.

Applications in Scientific Research

  • Coenzyme Q10 is widely used in the study of mitochondrial dysfunction, aging, and energy metabolism.
  • Due to its role in energy production, it is commonly studied in relation to heart failure, ischemia, and statin-induced myopathy.
  • Investigated for therapeutic effects in Parkinson’s, Alzheimer’s, and Huntington’s diseases.
  • Employed in in vitro and in vivo models to examine antioxidant defenses.
  • Utilized in assays investigating mitochondrial function, lipid peroxidation, and redox cycling.

Packaging & Storage

  • Available as yellow or orange-yellow lyophilized powder
  • Store at 15°C to 25°C in tightly sealed containers, protected from moisture and light

References

  1. Bentinger M. et al. 2010: Coenzyme Q--biosynthesis and functions, Biochem Biophys Res Commun. 396(1):74-9.
  2. Ernster L & Dallner G. 1995: Biochemical, physiological, and medical aspects of ubiquinone function, Biochim Biophys Acta 1271(1):195-204.
  3. Littarru GP, Tiano L. 2007: Bioenergetic and antioxidant properties of coenzyme Q10: recent developments , Mol Biotechnol. 37(1):31-7.
  4. Gout I. 2018: Coenzyme A, protein CoAlation and redox regulation in mammalian cells , Biochem Soc Trans. 46(3):721-728.
  5. Pierrel F. et al. 2022: Recent advances in the metabolic pathways and microbial production of coenzyme Q , World J Microbiol Biotechnol. 38(4):58.
  6. Fan J. et al. 2022: Production of Coenzyme Q10 by microbes: an update , World J Microbiol Biotechnol. 38(11):194.
  7. Lu W. et al. 2014: Enhanced production of coenzyme Q10 by self-regulating the engineered MEP pathway in Rhodobacter sphaeroides , Biotechnol Bioeng. 111(4):761-9.
  8. Burgardt A. et al. 2021: Coenzyme Q10 biosynthesis established in the non-ubiquinone containing Corynebacterium glutamicum by metabolic engineering , Front Bioeng Biotechnol. 9:650961.
  9. Cheng B. 2010: Enhanced production of coenzyme Q10 by overexpressing HMG-CoA reductase and induction with arachidonic acid in Schizosaccharomyces pombe , Appl Biochem Biotechnol. 160(2):523-31.
  10. Abby SS. et al. 2020: Advances in bacterial pathways for the biosynthesis of ubiquinone , Biochim Biophys Acta – Bioenergetics. 1861(11):148259.
  11. Youself AO. et al. 2019: The neuroprotective role of Coenzyme Q10 against lead acetate-induced neurotoxicity is mediated by antioxidant, anti-inflammatory and anti-apoptotic activities , Int J Environ Res Public Health. 16(16):2895.
  12. Soja AM, Mortensen SA. 1997: Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials , Mol Aspects Med. 18 Suppl: S159-68.

Jiagen Biotechnologies supplies quality Coenzyme Q10 of various specifications.
Contact us at sales@jiagen.ca to place an order.

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