- Provides mechanical strength to skin, bone, cartilage, tendons, and ligaments
- Promotes tissue regeneration and wound healing
- Stimulates extracellular matrix (ECM) production in cells
- Modulates cell adhesion, migration, and differentiation
Collagen
| CAS No: | 9007-34-5 |
| EINECS No: | 232-697-4 |
| Synonyms: | Hydrolyzed collagen, Collagen peptides, Gelatin, Native collagen, Atelocollagen, Type I/II/III collagen, Bovine/Porcine/Fish collagen |
Product Summary
Collagen is the most abundant structural protein in animals, accounting for approximately 30% of total body protein. It plays a fundamental role in maintaining the integrity, strength, and elasticity of tissues.
Function
Mechanism of Action
- Collagen interacts with cell surface integrins (e.g., α1β1, α2β1), initiating signal transduction pathways (e.g., FAK, MAPK) that influence cell behavior
- Upon enzymatic or heat hydrolysis, collagen peptides can be absorbed in the gastrointestinal tract and stimulate fibroblast proliferation and hyaluronic acid synthesis
- Type-specific effects:
- Type I: Bone, skin, tendon
- Type II: Cartilage
- Type III: Skin, blood vessels
Applications in Scientific Research
- Used as a scaffold in tissue engineering and regenerative medicine
- Common substrate for cell culture (e.g., fibroblasts, chondrocytes, keratinocytes)
- Evaluates cell–ECM interactions, wound healing, and biomaterial integration
Packaging & Storage
- Store in a cool and dry place, protected from light
References
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- Andriotis OG, et al. 2018: Collagen fibrils: nature’s highly tunable nonlinear springs, ACS Nano 12(4):3671–3680.
- Wang H. 2021: A Review of the Effects of Collagen Treatment in Clinical Studies, Polymers (Basel) 13(22):3868.
- Dong C, Lv Y. 2016: Application of collagen scaffold in tissue engineering: recent advances and new perspectives, Polymers (Basel) 8(2):42.
- Goldberga I, et al. 2018: Collagen Structure–Function Relationships from Solid-State NMR Spectroscopy, Acc. Chem. Res. 51(7):1621–29.
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- Ashokkumar M, Ajayan PM. 2021: Materials science perspective of multifunctional materials derived from collagen, Int. Mater. Rev. 66(3).
- Tronci G, et al. 2015: Multi-scale mechanical characterization of highly swollen photo-activated collagen hydrogels, J R Soc Interface 12(102):20141079.
- Wang H, et al. 2014: Long range force transmission in fibrous matrices enabled by tension-driven alignment of fibers, Biophys J. 107(11):2592-603.
- Kamml J, et al. 2023: The influence of AGEs and enzymatic cross-links on the mechanical properties of collagen fibrils, Mat Sci & Engin C 106:110105.